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Download file# Volume of Pharmaceutical Powders Probed by Frequency-Domain Photon Migration Measurements of Multiply Scattered Light

journal contribution

posted on 28.06.2002, 00:00 by Tianshu Pan, Eva M. Sevick-MuracaUsing probability distribution analysis to describe the
propagation of multiply scattered light between a point
source and point detector located a known distance apart,
mathematical expressions predicting the volume of
sampled powder were determined for infinite and semi-infinite powder beds and then compared to experimental
measurements of frequency-domain photon migration
(FDPM). Our results show that the volume of powder
sampled varies with optical properties and, when using
FDPM techniques, with modulation frequency. For a
typical measurement in lactose powder, the volume of
powder sampled by multiply scattered light propagating
between a 1000-μm-diameter point source and point
detector pair separated by 8 mm is predicted to be 1.8
and 1.5 cm

^{3}at modulated frequencies of 50 and 100 MHz, respectively. Experimental measurements in lactose powder confirm the predictions.